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S.et al (2022)

You should not take cyanocobalamin-based products if you: Have a known cobalt allergy Have Lebers hereditary optic neuropathy , as B12 can worsen vision in this condition Discuss nasal B12 with your clinician first if you have: Severe megaloblastic anemia Polycythemia vera or other bone marrow disorders Low iron or folate Kidney disease Are undergoing chemotherapy or using bone marrowsuppressing drugs Are pregnant or breastfeeding Possible Side Effects Most side effects reported with B12 nasal products are mild and temporary: Slight nasal irritation, burning, or dryness Runny or stuffy nose, sneezing, or sore throat Mild headache Nausea or a brief metallic taste Tingling or pins and needles sensations, especially early on as nerves recover Serious reactions are rare but require immediate medical care: Rash, hives, or intense itching Swelling of the face, lips, tongue, or throat Trouble breathing or swallowing Fever, chills, or signs of infection that dont match a simple cold If anything feels out of proportion or youre unsure, stop the product and speak with your healthcare provider or seek urgent care

Disclaimer: This drug has not been found by FDA to be safe and effective, and this labeling has not been approved by FDA

Strong social bonds markedly predict longevity and shape health behaviors, often exerting effects comparable to or greater than classic risk factors (e.g., smoking, inactivity)

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CV safety is currently under investigation for tirzepatide in patients with obesity without diabetes (NCT05556512) and for cagrilintide/semaglutide with overweight and obesity with and without diabetes (NCT05669755)